Regulation of Redox Profile and Genomic Instability by Physical Exercise Contributes to Neuroprotection in Mice with Experimental Glioblastoma

Glioblastoma (GBM) is an aggressive, common brain cancer known to disrupt redox biology, affecting behavior and DNA integrity. Past research remains inconclusive. To further understand this, investigation was conducted on physical training’s effects behavior, balance, genomic stability in GBMA models. Forty-seven male C57BL/6J mice, 60 days old, were divided into GBM sham groups (n = 15, n 10, respectively), which subdivided trained (Str, Gtr; 12) untrained (Sut, Gut; 15) subsets. The mice performed moderate aerobic exercises a treadmill five six times week for month while remained their enclosures. Behavior evaluated using open-field rotarod tests. Post training, the euthanized brain, liver, bone marrow, blood samples analyzed instability markers. results indicated increased latency values (Gtr) group, suggesting beneficial impact of exercise. Elevated reactive oxygen species parietal tissue (Gut) reduced post training. Moreover, Gtr exhibited lower tail intensity, indicating less instability. Thus, exercise could serve as promising supplemental treatment, modulating parameters reducing